Contrary to what we and many others had assumed, the new Runewords introduced in Season One will remain craftable ONLY by Ladder characters. Flickering Flame, Wisdom, Unbending Will, Mist, Plague, and Obsession were all generally useful Runewords, but they will remain primarily Ladder only for now.
So, don’t spend valuable runes trying to make one of these in Non-Season play! This was confirmed recently by a tweet from Adam Fletcher, Blizzard Diablo Community Manager.