Several bugs potentially related to multiplayer have begun cropping up within the first few of days of Diablo 4’s Early Access. First, an issue with the Act 2 quest As the World Burns has seemingly locked players out of completing it if they have initiated the quest as a group.
As the World Burns Quest Issues
From the Official Diablo 4 Forums:
I killed Astaroth 3 times (Quest As the World Burns) 2 times in party ona time solo.